Scientific theories of abiogenesis propose that RNA was the primordial biological molecule that evolved prior to DNA and proteins

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Gut microbes synthesize short-chain fatty acids including butyrate, acetate, and propionate that deliver anti-inflammatory signals to the human host

Short-chain fatty acids including butyrate, acetate, and propionate repair tight junctions in the gut lining

Viome's laboratory utilizes RNA sequencing assays to measure dynamic gene expression in human and microbial cells rather than static DNA

Trimethylamine produced by gut bacteria travels through the bloodstream and is oxidized in the human liver into trimethylamine N-oxide, a compound linked to heart disease

Viome collects stool, saliva, and finger-prick blood samples from users to analyze human and microbial systems biology

Depending on which specific regions of the Akkermansia muciniphila genome are expressed, Akkermansia muciniphila can either produce anti-inflammatory fatty acids or contribute to diseases such as multiple sclerosis

Nobel laureate Thomas Cech authored the book The Catalyst about the biochemical properties of RNA

Viome models gut biochemical pathways by analyzing RNA transcript activity and covariance of KEGG Ortholog clusters

Viome applies unsupervised machine learning methods including Principal Component Analysis, Independent Component Analysis, and Non-negative Matrix Factorization to transcriptomic data

The sensory experience of smelling food during preparation triggers an increase in digestive enzyme secretion

The human microbiome contains approximately 2 million genes, which is roughly 100 times the gene count of the human genome

The human body contains an estimated 1.3 microbial cells for every human cell

Butyrate produced by gut microbes is rapidly absorbed by the gut lining upon generation, making fecal butyrate levels a weak proxy for intestinal butyrate production

The gut bacterium Akkermansia muciniphila possesses approximately 3,000 genes

Infants delivered via natural childbirth inherit more genes from the maternal microbiome than from the maternal human genome

Viome's Pro testing kit generates approximately 90 million sequencing reads across stool, saliva, and blood samples

Viome developed an autonomous discovery engine designed to evaluate functional biological models across a hypothesis search space of 10 to the 80th power configurations

The Kyoto Encyclopedia of Genes and Genomes catalogs biochemical pathways into functional gene clusters known as KEGG Orthologs

The Google DeepMind AlphaFold model uses neural networks combined with biological domain knowledge to predict the 3D structures of folded proteins from amino acid sequences

Gram-negative gut bacteria can produce inflammatory lipopolysaccharides that loosen tight junctions in the intestinal epithelium