Over 1,000 distinct genetic loci have been associated with obesity risk in human genome-wide association studies

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GLP-1 receptor agonist medications suppress appetite by targeting neural signaling pathways that regulate hunger and body weight settling points

Rural farming populations in northern Rwanda consuming high-carbohydrate diets display virtually no cases of obesity

In the United States, approximately 42% of adults are classified as obese

Approximately 50% to 60% of patients prescribed GLP-1 receptor agonist medications discontinue treatment within a few years

Rapid weight loss from GLP-1 receptor agonists often includes substantial reductions in skeletal muscle mass alongside fat loss

Populations in northern Rwanda experience sharp increases in obesity and type 2 diabetes following migration into urban environments

Adult obesity rates in the United States quadrupled between the mid-twentieth century and the 2020s

Approximately 72% of adults in the United States are classified as either overweight or obese based on body mass index

Heritability studies estimate that genetic variation explains between 30% and 70% of population-level body weight variation

Known obesity-associated genetic variants collectively account for between 6% and 17% of total variance in body weight

Gut microbes synthesize short-chain fatty acids including butyrate, acetate, and propionate that deliver anti-inflammatory signals to the human host

Short-chain fatty acids including butyrate, acetate, and propionate repair tight junctions in the gut lining

Scientific theories of abiogenesis propose that RNA was the primordial biological molecule that evolved prior to DNA and proteins

Viome's laboratory utilizes RNA sequencing assays to measure dynamic gene expression in human and microbial cells rather than static DNA

Trimethylamine produced by gut bacteria travels through the bloodstream and is oxidized in the human liver into trimethylamine N-oxide, a compound linked to heart disease

Viome collects stool, saliva, and finger-prick blood samples from users to analyze human and microbial systems biology

Depending on which specific regions of the Akkermansia muciniphila genome are expressed, Akkermansia muciniphila can either produce anti-inflammatory fatty acids or contribute to diseases such as multiple sclerosis

Nobel laureate Thomas Cech authored the book The Catalyst about the biochemical properties of RNA

Viome models gut biochemical pathways by analyzing RNA transcript activity and covariance of KEGG Ortholog clusters

Viome applies unsupervised machine learning methods including Principal Component Analysis, Independent Component Analysis, and Non-negative Matrix Factorization to transcriptomic data