The United States Food and Drug Administration has approved ketamine for the clinical treatment of treatment-refractory depression

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Nicholas Guerrel developed the Montreal Model, which combines in-clinic ketamine administration with psychotherapy to treat depression and co-occurring alcohol use disorder

Omega-3 fatty acid deficiencies contribute to depression, dementia, ADHD, and bipolar disorder

MDMA was utilized legally as a couples therapy medication for 15 years prior to its scheduling and prohibition

A Swiss pharmaceutical company legally sold LSD to psychiatrists as a prescription drug for nearly 20 years prior to its prohibition

Ketamine acts pharmacologically as a dissociative anesthetic by blocking NMDA receptors in the nervous system

Paroxetine, sold under the brand name Paxil, is an antidepressant prescribed for major depressive disorder

High-functioning depression is characterized by maintaining high outward performance and daily responsibilities while experiencing persistent anhedonia and an inability to feel joy

Psychologist Jonathan Rottenberg is the author of 'The Evolutionary Origins of the Depression Epidemic'

Terry Bradshaw sought help from a preacher, a marriage counselor, a psychologist, and a psychiatrist over a full year before being diagnosed with clinical depression

Terry Bradshaw attended psychotherapy for three consecutive years to understand the psychological triggers of his depression

Terry Bradshaw uses the alter-ego name 'Roy' to describe the quiet, dark persona that manifests during Terry Bradshaw's depressive episodes

Katherine May experienced a period of severe depression at 17 years old

Terry Bradshaw manages his diagnosed clinical depression through daily prescription medication

A psychiatrist diagnosed Terry Bradshaw with clinical depression and prescribed medication to treat it

Transcranial magnetic stimulation (TMS) is used to modulate brain network activity in cases of treatment-resistant depression

Psychiatric disorders characterized by emotional flattening or depression frequently display metabolic abnormalities in the limbic system on neuroimaging

In women, depressive states and unhappy mood states are typically associated with abnormally low estrogen levels

Epidemiological studies link high intake of ultra-processed food to increased incidence of depression, anxiety, psychosis, and dementia

In the SMILES randomized controlled trial for major depression, approximately 30% of participants receiving a gut-friendly dietary intervention achieved full symptom remission

In the SMILES randomized controlled trial, adopting a high-fiber, plant-rich diet produced greater reductions in depression and anxiety symptoms than pharmacological antidepressant treatment alone