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Dissolving creatine in hot liquid yields higher peak blood plasma levels than consuming it in cold liquid

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More than 680 clinical trials with over 12,000 participants have examined creatine since the 1970s

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Creatine acts as a biochemical buffer facilitating the rapid regeneration of cellular adenosine triphosphate (ATP) in brain and muscle tissue

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Vegetarians start with significantly lower baseline concentrations of intramuscular and cerebral creatine compared to omnivores

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In sleep-deprived subjects, a single high dose of creatine improved cognitive processing capacity and short-term memory