The University of Rochester Medicine study showed that circadian interventions in mice after a stroke led to lower levels of inflammatory cytokines in the brain.

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Mice deficient in ENT1 exhibited reduced liver adenosine levels and protection against inflammation, fibrosis, and excessive liver fat accumulation.

Inflammatory bowel disease treatments rely on anti-inflammatory and immune-suppressing drugs, though many patients fail to respond to these medications.

When consumed through red meat, Neu5Gc accumulates in human tissues as a foreign xeno-autoantigen, triggering antibody responses and persistent inflammation known as xenosialitis.

Ulcerative colitis is a chronic inflammatory condition causing inflammation and ulcers in the digestive tract of affected patients

Satralizumab is a humanized monoclonal antibody designed to bind to soluble and membrane-bound interleukin-6 receptors, inhibiting interleukin-6-mediated inflammatory signaling

Oregon Health & Science University circadian physiologist Andrew McHill stated that eating during the night when the internal biological clock promotes sleep reduces nutrient metabolism efficiency, potentially leading to obesity, diabetes, and impaired liver health.

Previous animal model studies showed that the liver is among the organs most susceptible to misalignment between eating and sleep timing.

Night shift workers whose work schedules conflict with natural day-night biological cycles experience elevated rates of obesity and heart disease.

Clinical research shows semaglutide slows kidney disease progression through mechanisms including blood sugar, blood pressure, and inflammation improvements.

Semaglutide administration improved liver tissue findings, including reduced inflammation and liver scarring, among patients with metabolic dysfunction-associated steatohepatitis in a New England Journal of Medicine trial.

FB102 is designed to block CD122 to selectively modulate IL-2 and IL-15 pathways that cause inflammation while preserving regulatory T-cell function and immune balance.

The Lancet review linked excessive digital media use to decreased physical activity and sleep disruption during critical phases of neurobiological development.

Disrupted sleep from digital device use may encourage unhealthy coping behaviors and stressful digital experiences in early adolescence.

Nighttime smartphone use can disrupt sleep, which is linked to altered appetite regulation and heightened emotional reactivity in adolescents.

A National Jewish Health study in JCI Insight showed that a five-day e-cigarette vapor exposure caused lasting changes in Th1 immunity, weakening antiviral defenses and increasing susceptibility to respiratory infections.

Karl Deisseroth used optogenetics in animal models to control mouse whisker movements by activating motor cortex nerve cells and to wake sleeping mice by stimulating wakefulness-controlling neurons

In preclinical testing, the experimental compound GPPD simultaneously improved fat accumulation, inflammation, liver injury, and fibrosis while demonstrating an encouraging safety profile with no significant toxicity.

A preclinical study co-led by Cedars-Sinai Health Sciences University identified UBE2N as a potential therapeutic target; restoring its levels in laboratory mice reduced fat accumulation, inflammation, and scarring, suggesting its potential to prevent MASLD from advancing to MASH.

Daxdilimab targets and depletes plasmacytoid dendritic cells, whereas litifilimab targets BDCA2 receptors on plasmacytoid dendritic cells to downregulate them without causing depletion

Daxdilimab is an investigational human immunoglobulin G subclass 1 monoclonal antibody that binds to immunoglobulin-like transcript 7, resulting in a targeted depletion of plasmacytoid dendritic cells associated with inflammation and skin lesions in cutaneous lupus erythematosus