Treatment-resistant depression is estimated to affect approximately 4 million people in the U.S., with fewer than 5% receiving a treatment indicated for the condition.

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In England, estimated financial costs from adverse childhood experiences were £37.8 billion for mental illness and £22.7 billion for smoking, while in Wales each accounted for £1.8 billion.

The American College of Obstetricians and Gynecologists noted that more than one in three perimenopausal and postmenopausal women report depressive symptoms

The Treatment-Resistant Depression Awareness Day campaign is supported by the National Alliance on Mental Illness, Mental Health America, and the Depression and Bipolar Support Alliance.

Compass Pathways announced the establishment of the first Treatment-Resistant Depression Awareness Day in the U.S. on October 14, 2026.

A survey commissioned by Compass Pathways revealed that nearly two in three caregivers report treatment-resistant depression impacts family health, with over half experiencing a major toll on their own mental health.

A survey commissioned by Compass Pathways found that nearly 95% of individuals living with treatment-resistant depression describe themselves as functioning but struggling, surviving day-to-day, or barely getting by.

Approximately one in six Americans take an antidepressant medication, and average duration of use has surpassed five years.

Outro plans to expand its tapering model into additional medication classes beyond antidepressants, including benzodiazepines, gabapentinoids, and GLP-1s.

Research led by Dr. Mark Horowitz found that four in five long-term antidepressant users were unable to stop taking their medications due to withdrawal symptoms.

FDA approval standards based on short-term trials adequately protect long-term antidepressant users

Antidepressant medications were originally approved by the FDA based on 8-to-12-week clinical studies despite widespread long-term usage.

The UK government-commissioned review, led by Professor Peter Fonagy, found that approximately one in four people aged 16 to 24 in the UK reports a common mental health problem, such as anxiety or depression

The Lancet review found consistent associations between problematic digital media use and increased risks of depression, anxiety, and sleep disruption in young people.

Researchers are using optogenetics in animal models to study the cellular mechanisms of schizophrenia, Alzheimer's disease, Parkinson's disease, epilepsy, depression, and addiction

Idiopathic nephrotic syndrome is frequently diagnosed in childhood, and its unpredictable relapses can cause anxiety, depression, and reduced self-esteem in young patients.

Previous studies have found that wildfires and other environmental crises can cause long-term human health impacts, including lung issues and depression.

Alopecia areata in pediatric patients is associated with increased rates of anxiety and depression, representing a significant psychiatric burden during adolescence.

More than 6% of users of the Mirena intrauterine device experience depression as a side effect, which is double the rate of depression reported by men in a 2008-2012 male contraceptive injection trial.

Approximately 20% of women stop using birth control or change their contraceptive methods within the first six months, frequently due to mood-related side effects such as depression.

Definium Therapeutics is currently recruiting for Ascend, a second study of DT120 Orally Disintegrating Tablet in major depressive disorder, and plans to launch a phase 3 study for post-traumatic stress disorder in 2027.