Interrupting tormenting nightly nightmares allows post-traumatic stress disorder patients to achieve restful sleep

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Childhood trauma leads people to develop psychosis

Trauma-informed support approaches aim to provide effective support for affected individuals by accounting for how past adversity impacts ongoing service interaction and behavior.

Preventing childhood adversity can be achieved by supporting parents, building life skills, challenging harmful social norms, and addressing social pressures on families.

Reducing childhood trauma exposure improves lifelong health while potentially lowering broader societal monetary costs associated with premature death and disease.

The Trauma-informed Wales Framework establishes a societal approach to understanding and responding to trauma, recognizing how past experiences shape adult needs and behavior.

Adults exposed to childhood adversity face heightened risks of mental illness, chronic physical conditions, health-harming behaviors, and poorer education and employment outcomes.

Previous animal model studies showed that the liver is among the organs most susceptible to misalignment between eating and sleep timing.

Night shift workers whose work schedules conflict with natural day-night biological cycles experience elevated rates of obesity and heart disease.

The Department of Health and Human Services is funding early-stage clinical trials of ibogaine to treat opioid addiction and post-traumatic stress disorder through ARPA-H and NIDA.

The Lancet review linked excessive digital media use to decreased physical activity and sleep disruption during critical phases of neurobiological development.

Disrupted sleep from digital device use may encourage unhealthy coping behaviors and stressful digital experiences in early adolescence.

Nighttime smartphone use can disrupt sleep, which is linked to altered appetite regulation and heightened emotional reactivity in adolescents.

The Department of Health and Human Services is prioritizing adults with post-traumatic stress disorder as one of two initial populations for federally supported ibogaine research.

Karl Deisseroth used optogenetics in animal models to control mouse whisker movements by activating motor cortex nerve cells and to wake sleeping mice by stimulating wakefulness-controlling neurons

A University of Rochester Medicine study published in the Journal of Clinical Investigation found that reinforcing circadian rhythms improved stroke recovery in mouse models.

Researchers at University of Rochester Medicine found that administering the clock-targeting drug KL001 or time-restricted feeding to mice three days after a stroke improved motor recovery and reduced brain lesion volumes.

The University of Rochester Medicine study showed that circadian interventions in mice after a stroke led to lower levels of inflammatory cytokines in the brain.

University of Rochester Medicine researchers suggest that stroke impairs glymphatic function, causing a failure in the clearance of inflammatory signaling molecules that leads to tissue damage.

Research by Lauren Hablitz and Maiken Nedergaard in 2020 established that glymphatic system function follows daily cycles regulated by circadian rhythms, independent of sleep.

Lead author Lauren Hablitz of University of Rochester Medicine characterized stroke as a disorder of timing, noting that strokes frequently occur in the morning and are often more severe near the end of sleep.