In individuals who later developed Crohn's disease, elevated antibody responses against herpesviruses, including Epstein-Barr virus, and anti-flagellin antibodies were observed up to 10 years before clinical diagnosis.

From the articleWarning signs could predict inflammatory bowel disease a decade before diagnosisAlso in Antibody patterns may predict inflammatory bowel disease years before diagnosis, Immune changes could signal inflammatory bowel disease up to 10 years before diagnosis