Entities: 261, 983
Products: 20,241
Active Chemicals: 2,648
RxNorm. Bethesda (MD): National Library of Medicine (US); [cited 2026]. source_url: https://rxnorm.nlm.nih.gov/
PubChem. Bethesda (MD): National Library of Medicine (US); [cited 2026]. source_url: https://pubchem.ncbi.nlm.nih.gov/
DailyMed. Bethesda (MD): National Library of Medicine (US); [cited 2026]. source_url: https://dailymed.nlm.nih.gov/
Top 100: Medical Expenditure Panel Survey; Agency for Healthcare Research and Quality. 2023 Prescribed Medicines File source_url: https://meps.ahrq.gov/mepsweb/data_stats/download_data_files_detail.jsp?cboPufNumber=HC-248A
CHEMISTRY & CLASSIFICATION
WHO ATC (https://www.whocc.no/atc_ddd_index/) — Anatomical-therapeutic-chemical classification for drugs worldwide.
RxNorm (https://www.nlm.nih.gov/research/umls/rxnorm/) — Clinical drug vocabularies linking branded names to ingredients and NDCs.
PubChem (https://pubchem.ncbi.nlm.nih.gov/) — Chemical structures, bioassay data, and cross-database identifiers.
DrugBank (https://go.drugbank.com/) — Comprehensive targets, PK parameters, and mechanism classifications.
STITCH (http://stitch.embl.de/) — Protein-chemical interaction networks for mechanism discovery.
BindingDB (https://www.bindingdb.org/) — Binding affinity constants for pharmacodynamic quantification.
Human Protein Atlas (https://www.proteinatlas.org/) — Tissue expression patterns for mechanism context and toxicity prediction.
CLINICAL & DOSING
DailyMed Pregnancy/Lactation (https://dailymed.nlm.nih.gov/) — PLLR narrative risk summaries replacing old pregnancy categories.
ICD-10-CM (https://www.cms.gov/medicare/icd-10) — Standard diagnosis codes for mapping indications and outcomes.
SNOMED CT (https://www.snomed.org/) — Clinical terminology for interoperability across EHR systems.
IDSA Guidelines (https://www.idsociety.org/practice-guideline/) — Infectious disease dosing tables and antimicrobial stewardship.
EASD Guidelines (https://easd.org/guidances.html) — Diabetes treatment algorithms with A1C targets and medication sequencing.
ACC/AHA Guidelines (https://professional.heart.org/en/guidelines) — Cardiology protocols for guideline-directed medical therapy.
STOPP/START (https://link.springer.com/article/10.1007/s40266-022-00959-0) — Screening tools for prescribing appropriateness in elderly patients.
LactMed (https://www.ncbi.nlm.nih.gov/books/NBK501922/) — Evidence-based lactation safety data compiled by NIH.
MotherToBaby (https://mothertobaby.org/) — Pregnancy exposure risk counseling and teratogen information.
PHARMACOLOGY & INTERACTIONS
FDA DDI Guidance (https://www.fda.gov/drugs/drug-interactions-labeling/) — CYP substrate/inhibitor/inducer classifications from FDA guidance.
CredibleMeds (https://www.crediblemeds.org/) — QT prolongation risk stratification and TdP risk categories.
SuperCYP (http://bioinformatics.charite.de/supercyp/) — CYP450 specificity and kinetics for metabolic pathway mapping.
REGULATORY & APPROVALS
Drugs@FDA (https://www.accessdata.fda.gov/scripts/cder/daf/) — Approval documents, label history, and NDA/BLA metadata.
FDA Orange Book (https://www.accessdata.fda.gov/scripts/cder/ob/index.cfm) — Therapeutic equivalence codes indicating generic substitutability.
FDA Purple Book (https://purplebook.fda.gov/) — Biosimilars and interchangeability determinations.
FDA REMS (https://www.accessdata.fda.gov/scripts/cder/rems/) — Risk evaluation and mitigation strategies with access restrictions.
USPTO Patent Search (https://ppubs.uspto.gov/pubwebapp/static/pages/landing.html) — Patent expiry dates, PTE extensions, and term adjustments.
EVIDENCE & TRIALS
NCCN Guidelines (https://www.nccn.org/professionals/physician_gls/) — Cancer treatment protocols and line of therapy guidance.
ClinicalTrials.gov (https://clinicaltrials.gov/) — Investigational indications, sponsors, enrollment status, and results.
SUPPLY CHAIN & PRICING
FDA Drug Shortages (https://www.accessdata.fda.gov/scripts/drugshortages/) — Current and resolved shortages with reasons and expected resolution.
ASHP Shortage Resource (https://www.ashp.org/drug-shortages) — Clinician-focused shortage management with alternatives.
Medicaid NADAC (https://data.medicaid.gov/price-transparency/nadac) — Pharmacy acquisition costs updated weekly by CMS.
Medicare ASP (https://www.cms.gov/medicare/payment/part-b-drugs/average-sales-price) — Physician-administered drug pricing for Part B reimbursement.
HRSA 340B Database (https://340bopais.hrsa.gov/) — Covered entity pricing eligibility and ceiling price data.
SAFETY & PHARMACOVIGILANCE
FAERS (https://www.fda.gov/drugs/drug-safety-and-availability/fdas-adverse-event-reporting-system-faers) — Real-world adverse event reports by drug and reaction MedDRA term.
OpenFDA API (https://open.fda.gov/) — Free REST API aggregating FDA labels, events, recalls, and NDC data.
MedDRA (https://www.meddra.org/) — Standardized terminology for regulatory adverse event reporting.
VigiBase (https://www.who-umc.org/) — Global pharmacovigilance database from WHO for signal detection.
SIDER (http://sideeffects.embl.de/) — Side Effect Resource extracting ADRs from drug labels.
DATA MODELS & STANDARDS
OMOP CDM (https://ohdsi.github.io/CommonDataModel/) — Standard data model for observational health research.
Pillbox (NLM) (https://pillbox.nlm.nih.gov/) — Pill identification by imprint, shape, color, and size.
GUDID (UDI Database) (https://accessgudid.nlm.nih.gov/) — Medical device identification for combination products.